ea0081ep568 | Endocrine-Related Cancer | ECE2022
Han Minmin
, Cao Xiaoming
, Lin Xueming
, Lv Xiao
, Xue Ruizhi
, Zhang Chunduo
, Chen Bingjun
, Zhang Jian
, Li Mengnan
, Liu Yunfeng
Introduction: As a tumor-suppressor gene, armadillo repeat-containing 5 (ARMC5) gene regulates steroidogenesis and cell apoptosis in manner of second-hit model. Mutations of ARMC5 gene will disturb its normal function, leading to reduced cortisol synthesis and cell apoptosis, which is acknowledged as a frequent cause of primary bilateral macronodular adrenal hyperplasia (PBMAH). Not until another somatic ARMC5 mutation occur in germline mutation carriers, will they manifest as...